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IONIS PHARMACEUTICALS INC Director's Dealing 2012

Jan 3, 2012

30591_dirs_2012-01-03_fcf410b6-258a-43de-aefd-beda535c8dec.zip

Director's Dealing

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SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: ISIS PHARMACEUTICALS INC (ISIS)
CIK: 0000874015
Period of Report: 2012-01-03

Reporting Person: CROOKE STANLEY T (Director, Chairman, President, CEO)

Derivative Transactions

Date Security Exercise Price Code Shares A/D Expiration Underlying Ownership
2012-01-03 Employee Stock Option (right to buy) $7.25 A 107203 Acquired 2022-01-02 Common Stock (107203) Direct
2012-01-03 Employee Stock Option (right to buy) $7.25 A 11404 Acquired 2022-01-02 Common Stock (11404) Indirect

Footnotes

F1: Grant of 1/3/12 to reporting person of stock options under the Isis Pharmaceuticals, Inc. 1989 Stock Option Plan. 25% of the shares subject to the option will vest and become exercisable on 1/3/13. Thereafter, the remaining shares subject to the option vest and become exercisable in 36 equal monthly installments, at the rate of 26,801 shares per year. The option is exercisable as to 0 shares on 1/3/12.

F2: Grant of 1/3/12 to reporting person's wife of stock options under the Isis Pharmaceuticals, Inc. 1989 Stock Option Plan. 25% of the shares subject to the option will vest and become exercisable on 1/3/13. Thereafter, the remaining shares subject to the option vest and become exercisable in 36 equal monthly installments, at the rate of 2,851 shares per year. The option is exercisable as to 0 shares on 1/3/12.