IONIS PHARMACEUTICALS INC — Director's Dealing 2012

Jan 13, 2012

SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: ISIS PHARMACEUTICALS INC (ISIS)
CIK: 0000874015
Period of Report: 2012-01-13

Reporting Person: PARSHALL B LYNNE (Director, Director, COO)

Derivative Transactions

Date	Security	Exercise Price	Code	Shares	A/D	Expiration	Underlying	Ownership
2012-01-13	Employee Stock Option (right to buy)	$5.25	G	20000	Disposed	2013-01-02	Common Stock (20000)	Direct
2012-01-13	Employee Stock Option (right to buy)	$5.25	G	10000	Acquired	2013-01-02	Common Stock (10000)	Indirect
2012-01-13	Employee Stock Option (right to buy)	$5.25	G	10000	Acquired	2013-01-02	Common Stock (10000)	Indirect

Footnotes

F1: The reporting person transferred options to her two daughters who share reporting person's household, divided equally.