IONIS PHARMACEUTICALS INC — Director's Dealing 2012

Jun 13, 2012

SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: ISIS PHARMACEUTICALS INC (ISIS)
CIK: 0000874015
Period of Report: 2012-06-08

Reporting Person: WENDER JOSEPH H (Director)

Non-Derivative Transactions

Date	Security	Code	Shares	Price	A/D	Holdings After	Ownership
2012-06-12	Common Stock	M	10000	$8.15	Acquired	51000	Direct

Derivative Transactions

Date	Security	Exercise Price	Code	Shares	A/D	Expiration	Underlying	Ownership
2012-06-12	Director Stock Option (right to buy)	$8.15	M	10000	Disposed	2012-06-30	Common Stock (10000)	Direct

Footnotes

F1: Acquired as a result of exercising a stock option that was scheduled to expire on 6/30/12.