IONIS PHARMACEUTICALS INC — Director's Dealing 2012

Sep 17, 2012

SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: ISIS PHARMACEUTICALS INC (ISIS)
CIK: 0000874015
Period of Report: 2012-09-13

Reporting Person: CROOKE STANLEY T (Director, Chairman, CEO and President)

Non-Derivative Transactions

Date	Security	Code	Shares	Price	A/D	Holdings After	Ownership
2012-09-13	Common Stock	M	27074	$5.25	Acquired	27074	Direct
2012-09-13	Common Stock	S	27074	$14.55	Disposed	0	Direct

Derivative Transactions

Date	Security	Exercise Price	Code	Shares	A/D	Expiration	Underlying	Ownership
2012-09-13	Employee Stock Option (right to buy)	$5.25	M	27074	Disposed	2013-01-02	Common Stock (27074)	Direct

Holdings (Non-Derivative)

Security	Shares	Ownership
Common Stock	873391	Indirect

Footnotes

F1: Acquired as a result of exercising a stock option pursuant to a Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on 6/27/12.