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IONIS PHARMACEUTICALS INC Director's Dealing 2012

Jan 3, 2012

30591_dirs_2012-01-03_084d2e3f-39ac-48bf-8e13-67fad69afb99.zip

Director's Dealing

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SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: ISIS PHARMACEUTICALS INC (ISIS)
CIK: 0000874015
Period of Report: 2011-12-01

Reporting Person: BENNETT C FRANK (Senior Vice President)

Non-Derivative Transactions

Date Security Code Shares Price A/D Holdings After Ownership
2011-12-01 Common Stock J 324 $6.1285 Acquired 629 Direct

Derivative Transactions

Date Security Exercise Price Code Shares A/D Expiration Underlying Ownership
2012-01-03 Employee Stock Option (right to buy) $7.25 A 25013 Acquired 2022-01-02 Common Stock (25013) Direct

Footnotes

F1: Reporting 324 shares acquired under the Isis Pharmaceuticals, Inc. Amended and Restated 2000 Employee Stock Purchase Plan on January 1, 2012. These 324 shares may not be sold until July 2, 2012.

F2: Grant of 1/3/12 to reporting person of stock options under the Isis Pharmaceuticals, Inc. 1989 Stock Option Plan. 25% of the shares subject to the option will vest and become exercisable on 1/3/13. Thereafter, the remaining shares subject to the option vest and become exercisable in 36 equal monthly installments, at the rate of 6,253 shares per year. The option is exercisable as to 0 shares on 1/3/12.