IONIS PHARMACEUTICALS INC - Director's Dealing 2012

SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: ISIS PHARMACEUTICALS INC (ISIS)
CIK: 0000874015
Period of Report: 2011-12-30

Reporting Person: KLEIN JOSEPH III (Director)

Date	Security	Exercise Price	Code	Shares	A/D	Expiration	Underlying	Ownership
2011-12-30	Director Stock Option (right to buy)	$5.17	G	20000	Disposed	2015-12-12	Common Stock (20000)	Direct
2011-12-30	Director Stock Option (right to buy)	$5.93	G	12500	Disposed	2016-07-02	Common Stock (12500)	Direct
2011-12-30	Director Stock Option (right to buy)	$5.17	G	6666	Acquired	2015-12-12	Common Stock (6666)	Indirect
2011-12-30	Director Stock Option (right to buy)	$5.93	G	4167	Acquired	2016-07-02	Common Stock (4167)	Indirect
2011-12-30	Director Stock Option (right to buy)	$5.17	G	6667	Acquired	2015-12-12	Common Stock (6667)	Indirect
2011-12-30	Director Stock Option (right to buy)	$5.93	G	4166	Acquired	2016-07-02	Common Stock (4166)	Indirect
2011-12-30	Director Stock Option (right to buy)	$5.17	G	6667	Acquired	2015-12-12	Common Stock (6667)	Indirect
2011-12-30	Director Stock Option (right to buy)	$5.93	G	4167	Acquired	2016-07-02	Common Stock (4167)	Indirect

F1: The reporting person transfrerred options to trusts for his three children who share the reporting person's household.