IONIS PHARMACEUTICALS INC — Director's Dealing 2012

Oct 11, 2012

SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: Regulus Therapeutics Inc. (RGLS)
CIK: 0001505512
Period of Report: 2012-10-10

Reporting Person: ISIS PHARMACEUTICALS INC (10% Owner)

Non-Derivative Transactions

Date	Security	Code	Shares	Price	A/D	Holdings After	Ownership
2012-10-10	Common Stock	C	6299500	—	Acquired	6299500	Direct
2012-10-10	Common Stock	P	750000	$4.00	Acquired	7049500	Direct

Derivative Transactions

Date	Security	Exercise Price	Code	Shares	A/D	Expiration	Underlying	Ownership
2012-10-10	Series A Preferred Stock	$	C	6299500	Disposed		Common Stock (6299500)	Direct

Footnotes

F1: Upon the closing of the Issuer's initial public offering, every 2 shares of Series A Preferred Stock automatically converted into 1 share of Common Stock and had no expiration date.

F2: The shares were purchased at the Issuer's initial public offering.