ILLUMINA, INC. — Director's Dealing 2011

May 19, 2011

SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: ILLUMINA INC (ILMN)
CIK: 0001110803
Period of Report: 2011-05-17

Reporting Person: ORPIN TRISTAN (Sr VP & Chief Commercial Offic)

Non-Derivative Transactions

Date	Security	Code	Shares	Price	A/D	Holdings After	Ownership
2011-05-17	Common Stock	M	1667	$4.54	Acquired	38550	Direct
2011-05-17	Common Stock	S	1667	$74.19	Disposed	36883	Direct
2011-05-17	Common Stock	M	13333	$20.04	Acquired	50216	Direct
2011-05-17	Common Stock	S	13333	$74.19	Disposed	36883	Direct

Derivative Transactions

Date	Security	Exercise Price	Code	Shares	A/D	Expiration	Underlying	Ownership
2011-05-17	Non-Qualified Stock Option (right to buy)	$4.54	M	1667	Disposed	2015-01-20	Common Stock (1667)	Direct
2011-05-17	Non-Qualified Stock Option (right to buy)	$20.04	M	13333	Disposed	2017-01-25	Common Stock (13333)	Direct

Footnotes

F1: The sale was made pursuant to a 10b5-1 plan.