Compugen Ltd. — Director's Dealing 2026

Mar 18, 2026

FORM 3

UNITED STATES SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934

or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person* Ferre Pierre (Last) (First) (Middle) C/O COMPUGEN LTD. 26 HAROKMIM STREET (Street) HOLON 5885849 (City) (State) (Zip/Postal Code) ISRAEL (Country)
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Table I – Non-Derivative Securities Beneficially Owned
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1. Title of Security (Instr. 4)
Table II – Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 4)	2. Date Exercisable and Expiration Date (Month/Day/Year)
	Date Exercisable
Share Option (right to buy)	(1)
Share Option (right to buy)	(2)
Share Option (right to buy)	(3)
Share Option (right to buy)	(4)
Share Option (right to buy)	(5)
Share Option (right to buy)	(6)

Explanation of Responses:

1. Fully vested.
2. This option vested $25\%$ on March 31, 2023 and the remainder vested or vests in 12 equal quarterly installments thereafter, subject to the Reporting Person's continued service to the Issuer.
3. This option vested $25\%$ on December 31, 2023 and the remainder vested or vests in 12 equal quarterly installments thereafter, subject to the Reporting Person's continued service to the Issuer.

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1. This option vested 25% on September 30, 2024 and the remainder vested or vests in 12 equal quarterly installments thereafter, subject to the Reporting Person's continued service to the Issuer.
2. This option vested 25% on September 30, 2025 and the remainder vested or vests in 12 equal quarterly installments thereafter, subject to the Reporting Person's continued service to the Issuer.
3. This option vests 25% on September 30, 2026 and the remainder vests in 12 equal quarterly installments thereafter, subject to the Reporting Person's continued service to the Issuer.

/s/ Pierre Ferre
** Signature of Reporting Person
03/18/2026
Date

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.

• If the form is filed by more than one reporting person, see Instruction 5(b)(v).
  ** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).

Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.

Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.