AMGEN INC — Director's Dealing 2021

May 5, 2021

SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: AMGEN INC (AMGN)
CIK: 0000318154
Period of Report: 2021-04-30

Reporting Person: Santos Esteban (EVP, Operations)

Non-Derivative Transactions

Date	Security	Code	Shares	Price	A/D	Holdings After	Ownership
2021-04-30	Common Stock	A	3964	—	Acquired	52444	Direct
2021-05-01	Common Stock	F	651	$239.64	Disposed	51793	Direct
2021-05-03	Common Stock	F	685	$239.64	Disposed	51108	Direct

Derivative Transactions

Date	Security	Exercise Price	Code	Shares	A/D	Expiration	Underlying	Ownership
2021-04-30	Nqso (Right to Buy)	$239.64	A	34420	Acquired	2031-04-30	Common Stock (34420)	Direct

Holdings (Non-Derivative)

Security	Shares	Ownership
Common Stock	776.9266	Indirect

Footnotes

F1: The Restricted Stock Units (RSUs) were granted pursuant to the Amgen Inc. 2009 Amended and Restated Equity Incentive Plan and vest in three annual installments of 33%, 33% and 34% on 4/30/2023, 4/30/2024 and 4/30/2025, respectively.

F2: These shares include the following RSUs granted under the Company's equity plans: 1,073 RSUs which will vest on 4/27/2022; 2,645 RSUs which vest in installments of 1,303 on 5/3/2022 and 1,342 on 5/3/2023; 3,384 RSUs which vest in installments of 1,116 on 5/5/2022, 1,117 on 5/5/2023 and 1,151 on 5/5/2024; and 3,964 RSUs which vest in two installments of 1,308 on 4/30/2023 and 4/30/2024 and 1,348 on 4/30/2025. Vested RSUs will be paid in shares of the Company's common stock on a one-to-one basis.

F3: These shares include 351 Dividend Equivalents (DEs) granted pursuant to the Amgen Inc. Amended and Restated 2009 Equity Incentive Plan and subject to a qualifying dividend reinvestment plan. DEs are credited to the reporting person's unvested RSUs and are paid out in shares of the Company's common stock on a one-to-one basis according to the vesting schedule, along with a cash payment for any remaining fractional share amount.

F4: These shares are acquired under the Company's 401(k) Plan and represent interests in the Company's stock fund as of this filing.

F5: These non-qualified stock options are exercisable in three installments of 33%, 33% and 34% on 4/30/2023, 4/30/2024 and 4/30/2025, respectively.