Alkermes plc. — Director's Dealing 2016

Dec 9, 2016

SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: Alkermes plc. (ALKS)
CIK: 0001520262
Period of Report: 2016-12-07

Reporting Person: FRATES JAMES M (SVP, Alks Inc; CFO ALKS)

Non-Derivative Transactions

Date	Security	Code	Shares	Price	A/D	Holdings After	Ownership
2016-12-07	Ordinary Shares	M	13731	$15.95	Acquired	126073	Direct
2016-12-07	Ordinary Shares	M	10000	$11.74	Acquired	136073	Direct
2016-12-07	Ordinary Shares	S	5496	$55.6454	Disposed	130577	Direct
2016-12-07	Ordinary Shares	S	17379	$56.4375	Disposed	113198	Direct
2016-12-07	Ordinary Shares	S	856	$57.2167	Disposed	112342	Direct

Derivative Transactions

Date	Security	Exercise Price	Code	Shares	A/D	Expiration	Underlying	Ownership
2016-12-07	Non Qualified Stock Option (Right to Buy)	$15.95	M	13731	Disposed	2017-06-01	Ordinary Shares (13731)	Direct
2016-12-07	Employee Stock Option (Right to Buy)	$11.74	M	10000	Disposed	2020-05-17	Ordinary Shares (10000)	Direct

Holdings (Non-Derivative)

Security	Shares	Ownership
Ordinary Shares	4000	Indirect
Ordinary Shares	41041	Indirect
Ordinary Shares	16562	Indirect
Ordinary Shares	11421	Indirect

Footnotes

F1: This option exercise was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

F2: Includes 18,579 shares received on December 5, 2016 pursuant to an annuity payment from the James M. Frates Grantor Retained Annuity Trust No. 2 dated November 25, 2015 (the "2015 GRAT No. 2") which was exempt from reporting obligations by virtue of Rule 16a-13 promulgated under the Securities Exchange Act of 1934, as amended.

F3: This sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

F4: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $55.09 to $56.08. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

F5: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $56.10 to $57.06. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

F6: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $57.14 to $57.33. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

F7: Shares held by James M. Frates Grantor Retained Annuity Trust dated March 14, 2014 (the "GRAT"). The Reporting Person is a trustee and beneficiary of the GRAT and may be deemed to hold voting and dispositive power with regard to the reported shares held by the GRAT.

F8: Shares held by the James M. Frates Grantor Retained Annuity Trust dated May 29, 2015 (the "2015 GRAT"). The Reporting Person is a trustee and beneficiary of the 2015 GRAT and may be deemed to hold voting and dispositive power with regard to the reported shares held by the 2015 GRAT.

F9: Shares held by the James M. Frates Grantor Retained Annuity Trust No. 2 dated November 25, 2015 (the "2015 GRAT No. 2"). The Reporting Person is a trustee and beneficiary of the 2015 GRAT No. 2 and may be deemed to hold voting and dispositive power with regard to the reported shares held by the 2015 GRAT No. 2.

F10: These options are fully vested in accordance with their terms.