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Acticor Biotech Capital/Financing Update 2024

Jul 18, 2024

1070_iss_2024-07-18_2fd9e70f-91e7-43e1-bf8f-a2632eef0327.pdf

Capital/Financing Update

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HALF-YEAR REPORT ON THE LIQUIDITY CONTRACT WITH THE BROKERAGE FIRM KEPLER CHEUVREUX

COMMUNIQUE DE PRESSE COMMUNIQUE DE PRESSE

Paris, France, July 18, 2024 – 6:00 pm CEST – ACTICOR BIOTECH (ISIN: FR0014005OJ5 – ALACT), a clinical stage biopharmaceutical company developing glenzocimab, an innovative drug for the treatment of cardiovascular emergencies, today announces its half-year report on the liquidity contract with the brokerage firm Kepler Cheuvreux.

Under the liquidity contract entered into between ACTICOR BIOTECH and Kepler Cheuvreux, the following resources appeared on the liquidity account on June 30th, 2024:

  • 245,176 shares
  • € 252,168.60
  • Number of executions on buy side on semester: 990
  • Number of executions on sell side on semester: 956
  • Traded volume on buy side on semester: 504,480 shares for € 524,812.30
  • Traded volume on sell side on semester: 324,426 shares for € 473,133.44

As a reminder:

  • the following resources appeared on the last half year statement on 31 December 2023 on the liquidity account:
    • 65,122 shares
    • € 299,098.61
    • Number of executions on buy side on semester: 340
    • Number of executions on sell side on semester: 227
    • Traded volume on buy side on semester: 39,590 shares for € 173,764.12
    • Traded volume on sell side on semester: 17,891 shares for € 85,132.33
  • the following resources appeared on the liquidity account when the activity started:
    • 0 shares
    • € 600,000.00

The implementation of this report is carried out in accordance with AMF Decision N°2021-01 of June 22nd 2021 renewing the implementation of liquidity contracts for shares as an accepted market practice.

About ACTICOR BIOTECH

Acticor Biotech is a clinical-stage biopharmaceutical company developing glenzocimab, an innovative drug for the treatment of cardiovascular emergencies, particularly ischemic stroke.

The positive results of the phase 1b/2a study, ACTIMIS, published in January 2024 in the Lancet Neurology (link to publication) confirmed the safety profile of glenzocimab and showed a reduction in mortality and intracerebral hemorrhage in the glenzocimab-treated group of stroke patients. A post-hoc analysis of brain imaging at 0 and 24 hours using artificial intelligence confirmed these results, showing a reduction in the number and volume of intracerebral lesions in patients treated with glenzocimab.

On April 25, 2024, the company announced the initial results of the international phase 2/3 ACTISAVE study in the treatment of acute ischemic stroke, which showed no efficacy of glenzocimab on the primary endpoint, the proportion of patients with severe disability or death (mRS 4-6) 90 days after stroke, nor on the secondary endpoint, the proportion of patients returning to life without disability (mRS 0-2).

On May 15, 2024, Prof. Martin Köhrmann (Principal Investigator of ACTISAVE) presented the main results of the study at the opening session of the European Stroke Organization Conference (ESOC), confirming the neutrality of the study on the primary and secondary endpoints, and showing trends in return to normal life (mRS 0-1), notably in sub-populations of patients with complete recanalization after mechanical thrombectomy.

Glenzocimab is being evaluated in 2 other clinical trials initiated by academic teams:

  • GREEN: a phase 2/3 study in the treatment of stroke in thrombectomized patients, with a futility analysis after inclusion of the first 78 patients (30% of patients) expected in Q4 2024;
  • LIBERATE: a Phase 2b LIBERATE trial in the treatment of myocardial infarction, with final results expected in Q4 2025.

Acticor Biotech is supported by a panel of European and international investors (Mediolanum farmaceutici, Karista, Go Capital, Newton Biocapital, CMS Medical Venture Investment (HK) Limited, A&B (HK) Limited, Anaxago, and the Armesa Foundation) and has been listed on Euronext Growth Paris since November 2021 (ISIN: FR0014005OJ5 - ALACT).

For more information, visit: www.acticor-biotech.com

Contacts

ACTICOR BIOTECH Gilles AVENARD, MD CEO and Founder [email protected] T. : +33 (0)6 76 23 38 13

Sophie BINAY, PhD General Manager and CSO [email protected] T. : +33 (0)6 76 23 38 13

NewCap Mathilde BOHIN Investor Relations [email protected] T. : +33 (0)1 44 71 94 95

NewCap Arthur ROUILLÉ Media Relations [email protected] T. : +33 (0)1 44 71 00 15

Buy Side Sell Side
Number of
executions
Number of
shares
Traded volume in
EUR
Number of
executions
Number of
shares
Traded volume in
EUR
Total 990 504,480 524,812.30 956 324,426 473,133.44
02/01/2024 1 250 725.00 2 250 737.50
05/01/2024 3 251 740.45 1 1 2.97
08/01/2024 - - - 8 750 2,257.50
09/01/2024 - - - 5 675 2,112.75
10/01/2024 1 100 306.00 3 25 79.00
11/01/2024 6 901 2,703.00 3 251 778.10
12/01/2024 6 1,223 3,510.01 4 501 1,477.95
15/01/2024 5 500 1,435.00 4 159 457.92
16/01/2024 2 250 710.00 4 108 312.12
17/01/2024 5 500 1,420.00 1 83 237.38
18/01/2024 1 1 2.84 3 501 1,437.87
19/01/2024 3 188 537.68 4 250 725.00
22/01/2024 - - - 4 750 2,227.50
23/01/2024 - - - 36 6,500 28,535.00
24/01/2024 - - - 38 5,726 30,004.24
25/01/2024 17 2,000 8,960.00 8 994 4,622.10
26/01/2024 6 750 3,232.50 3 402 1,776.84
29/01/2024 8 750 3,285.00 7 604 2,742.16
30/01/2024 4 463 2,046.46 3 750 3,367.50
31/01/2024 6 1,037 4,490.21 2 500 2,190.00
01/02/2024 12 1,000 4,260.00 - - -
02/02/2024 6 750 3,157.50 2 250 1,090.00
05/02/2024 7 500 2,100.00 5 501 2,134.26
06/02/2024 7 660 2,831.40 4 500 2,200.00
07/02/2024 5 395 1,666.90 3 501 2,169.33
08/02/2024 10 1,274 5,287.10 9 815 3,423.00
09/02/2024 4 267 1,148.10 5 686 3,018.40
12/02/2024 3 503 2,213.20 2 497 2,211.65
13/02/2024 4 731 3,135.99 1 1 4.43
14/02/2024 5 850 3,638.00 3 376 1,650.64
15/02/2024 2 399 1,687.77 - - -
16/02/2024 1 250 1,075.00 13 2,123 9,426.12
19/02/2024 3 250 1,100.00 1 250 1,125.00
20/02/2024 6 950 4
,284
.50
6 1
,250
5
,700
.00
21/02/2024 - - - 22 1
,877
8
,859
.44
22/02/2024 - - - 14 1
,623
8
,098
.77
23/02/2024 - - - 12 1
,250
6
,287
.50
26/02/2024 8 1
,250
6
,075
.00
2 456 2
,252
.64
27/02/2024 7 751 3
,717
.45
17 2
,244
11
,264
.88
28/02/2024 3 500 2
,510
.00
25 2
,001
10
,145
.07
29/02/2024 7 1
,001
4
,984
.98
15 999 5
,094
.90
01/03/2024 4 1
,000
5
,020
.00
21 3
,274
16
,992
.06
04/03/2024 27 1
,748
8
,477
.80
7 782 3
,831
.80
05/03/2024 1 5 24
.70
15 2
,718
13
,617
.18
06/03/2024 - - - 16 1
,750
8
,925
.00
07/03/2024 8 831 4
,188
.24
3 144 740
.16
08/03/2024 27 4
,998
22
,840
.86
9 988 4
,544
.80
11/03/2024 10 1
,940
8
,749
.40
8 689 3
,128
.06
12/03/2024 5 651 2
,942
.52
4 498 2
,280
.84
13/03/2024 6 950 4
,294
.00
5 514 2
,343
.84
14/03/2024 13 2
,576
11
,257
.12
8 702 3
,130
.92
15/03/2024 28 4
,721
15
,248
.83
- - -
18/03/2024 11 2
,500
8
,250
.00
- - -
19/03/2024 15 3
,100
9
,486
.00
- - -
20/03/2024 11 2
,750
7
,975
.00
- - -
21/03/2024 8 1
,272
3
,739
.68
- - -
22/03/2024 10 1
,978
5
,657
.08
- - -
25/03/2024 7 410 1
,271
.00
- - -
26/03/2024 3 97 300
.70
- - -
27/03/2024 3 252 806
.40
- - -
28/03/2024 2 498 1
,628
.46
- - -
02/04/2024 2 500 1
,635
.00
- - -
03/04/2024 2 500 1
,610
.00
- - -
04/04/2024 1 36 118
.80
- - -
05/04/2024 1 250 835
.00
- - -
08/04/2024 2 250 850
.00
- - -
09/04/2024 1 250 850
.00
- - -
10/04/2024 3 110 374
.00
- - -
11/04/2024 2 390 1
,337
.70
- - -
12/04/2024 4 500 1
,800
.00
- - -
15/04/2024 3 456 1
,673
.52
- - -
16/04/2024 7 664 2
,529
.84
2 500 1
,965
.00
17/04/2024 3 250 975
.00
3 699 2
,775
.03
18/04/2024 1 46 185
.84
4 301 1
,219
.05
19/04/2024 - - - 9 1
,318
5
,496
.06
22/04/2024 21 6
,943
26
,730
.55
17 2
,250
8
,775
.00
23/04/2024 3 199 754
.21
6 750 2
,887
.50
24/04/2024 9 2
,048
7
,864
.32
11 2
,250
9
,022
.50
25/04/2024 17 45
,000
13
,950
.00
- - -
26/04/2024 53 110
,000
42
,900
.00
- - -
29/04/2024 14 6
,518
2
,542
.02
7 5
,000
2
,100
.00
30/04/2024 23 17
,982
6
,653
.34
10 4
,000
1
,560
.00
02/05/2024 21 16
,355
6
,214
.90
7 6
,000
2
,520
.00
03/05/2024 1 1
,000
390
.00
1 1
,000
400
.00
06/05/2024 1 1
,000
400
.00
4 4
,000
1
,680
.00
07/05/2024 5 4
,000
2
,000
.00
48 32
,792
17
,051
.84
08/05/2024 5 4
,000
2
,840
.00
74 44
,208
32
,713
.92
09/05/2024 59 24
,740
20
,039
.40
31 14
,412
12
,394
.32
10/05/2024 16 11
,900
7
,735
.00
34 21
,180
16
,308
.60
13/05/2024 22 11
,700
8
,892
.00
14 8
,000
6
,320
.00
14/05/2024 8 6
,000
4
,620
.00
25 13
,000
10
,530
.00
15/05/2024 - - - 47 27
,593
28
,420
.79
16/05/2024 30 16
,406
15
,913
.82
18 11
,000
11
,550
.00
17/05/2024 7 7
,000
6
,650
.00
5 1
,227
1
,202
.46
20/05/2024 19 10
,094
9
,387
.42
9 3
,984
3
,784
.80
21/05/2024 17 9
,700
8
,827
.00
9 4
,625
4
,301
.25
22/05/2024 9 5
,000
4
,550
.00
7 2
,274
2
,092
.08
23/05/2024 6 5
,000
4
,350
.00
1 25 22
.75
24/05/2024 11 4
,004
3
,323
.32
- - -
27/05/2024 12 5
,996
4
,916
.72
- - -
28/05/2024 10 6
,000
4
,680
.00
- - -
29/05/2024 10 3
,428
2
,639
.56
4 3
,000
2
,370
.00
30/05/2024 21 13
,952
10
,045
.44
- - -
31/05/2024 8 4
,620
3
,095
.40
- - -
03/06/2024 - - - 10 4
,000
3
,240
.00
04/06/2024 - - - 41 24
,165
23
,681
.70
05/06/2024 - - - 7 4
,915
5
,603
.10
06/06/2024 11 8
,000
7
,520
.00
2 165 181
.50
07/06/2024 2 1
,000
920
.00
- - -
10/06/2024 13 10
,000
8
,600
.00
6 1
,000
880
.00
11/06/2024 9 4
,500
3
,780
.00
- - -
12/06/2024 7 4
,001
3
,280
.82
4 3
,001
2
,520
.84
13/06/2024 18 7
,866
6
,371
.46
1 424 360
.40
14/06/2024 27 22,134 15,493.80 31 4,587 3,256.77
17/06/2024 13 9,969 6,778.92 13 5,543 4,046.39
18/06/2024 - - - 16 4,300 3,010.00
19/06/2024 7 1,774 1,224.06 - - -
20/06/2024 5 1,226 858.20 8 4,800 3,552.00
24/06/2024 2 500 380.00 2 770 592.90
25/06/2024 12 5,000 3,700.00 5 398 302.48
26/06/2024 11 4,019 2,893.68 2 930 669.60
27/06/2024 3 1,001 710.71 1 1 0.72
28/06/2024 7 4,981 3,486.70 - - -